Hemodynamics driven cardiac valve morphogenesis

Trichloroethylene Exposure during Cardiac Valvuloseptal Morphogenesis Alters Cushion Formation and Cardiac Hemodynamics in the Avian Embryo

It is controversial whether trichloroethylene (TCE) is a cardiac teratogen. We exposed chick embryos to 0, 0.4, 8, or 400 ppb TCE/egg during the period of cardiac valvuloseptal morphogenesis (2-3.3 days' incubation) . Embryo survival, valvuloseptal cellularity, and cardiac hemodynamics were evaluated at times thereafter. TCE at 8 and 400 ppb/egg reduced embryo survival to day 6.25 incubation by...

Hemodynamics of aortic valve atresia.

Hemodynamic data on 12 infants with aortic valve atresia, ranging from 1 to 3 mo of age, are presented. Peripheral arterial oxygen saturations ranged from 19 to 93%. The lowest saturations were found in patients with closed foramen ovales. Increasing age, increasing pulmonary vascular resistance, and a decrease in the pulmonary-to-systemic blood flow ratio all correlated with decreasing systemi...

The Hemodynamics of Calcific Aortic Valve Disease

Morphological Plasticity: Environmentally Driven Morphogenesis

This paper focuses on the environmental role in morphogenesis in dynamic morphologies (DM). We discuss the benefits of morphological plasticity (MP) and introduce our Environment-Phenotype Map (E-P Map) framework in order to investigate and classify the continual development in DMs and morphologically adaptive behaviour. We present our MP-capable system the Artificial Cytoskeleton (ArtCyto), ho...

Metric-Driven Grammars and Morphogenesis

Expansion of space, rather than the progress of time, drives many developmental processes in plants. Metric-driven grammars provide a formal method for specifying and simulating such processes. We illustrate their operation using cell division patterns, phyllotactic patterns, and several aspects of leaf development.